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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9868966 B1

PDFFull Text
Expired
Date of Patent:
Jan. 16, 2018

Filed:

Oct. 10, 2013

Genetically engineered yeast

Applicant:

Technical University of Denmark, Kgs. Lyngby, DK;

Inventors:

Irina Borodina, Kgs. Lyngby, DK;

Kanchana Rueksomtawin Kildegaard, Kgs. Lyngby, DK;

Jochen Förster, Kgs. Lyngby, DK;

Fredrik Öberg, Kgs. Lyngby, DK;

Assignee:

TECHNICAL UNIVERSITY OF DENMARK, Kgs. Lyngby, DK;

Attorney:

Pillsbury Winthrop Shaw Pittman LLP

Primary Examiner:

Maryam Monshipouri

Int. Cl.
CPC ...
C12N 5/04 (2006.01); C12N 9/10 (2006.01); A01H 1/00 (2006.01); C12P 7/64 (2006.01); C12P 21/06 (2006.01); C12P 7/42 (2006.01); C12P 7/52 (2006.01); C12N 9/04 (2006.01); C12N 9/88 (2006.01); C12N 9/00 (2006.01);
U.S. Cl.
CPC ...
C12P 7/42 (2013.01); C12N 9/0006 (2013.01); C12N 9/1096 (2013.01); C12N 9/88 (2013.01); C12N 9/93 (2013.01); C12P 7/52 (2013.01); C12Y 101/01031 (2013.01); C12Y 101/01059 (2013.01); C12Y 206/01001 (2013.01); C12Y 401/01011 (2013.01); C12Y 401/01015 (2013.01); C12Y 604/01001 (2013.01);
Abstract

A genetically modifiedincluding an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA fromAH1272 catalyzing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.

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