The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2018
Filed:
Jun. 02, 2010
Duy P. Nguyen, Cambridge, GB;
Heinz Neumann, Gottingen, DE;
Alexander Deiters, Raleigh, NC (US);
Jason Chin, Cambridge, GB;
Hrvoje Lusic, Raleigh, NC (US);
Duy P. Nguyen, Cambridge, GB;
Heinz Neumann, Gottingen, DE;
Alexander Deiters, Raleigh, NC (US);
Jason Chin, Cambridge, GB;
Hrvoje Lusic, Raleigh, NC (US);
North Carolina State University, Raleigh, NC (US);
Medical Research Council, Swindon, GB;
Abstract
The invention relates to a method of making a polypeptide comprising an orthogonal functional group, said orthogonal functional group being comprised by an aliphatic amino acid or amino acid derivative, said method comprising providing a host cell; providing a nucleic acid encoding the polypeptide of interest; providing a tRNA-tRNA synthetase pair orthogonal to said host cell; adding an amino acid or amino acid derivative comprising the orthogonal functional group of interest, wherein said amino acid or amino acid derivative is a substrate for said orthogonal tRNA synthetase, wherein said amino acid or amino acid derivative has an aliphatic carbon backbone; and incubating to allow incorporation of said amino acid or amino acid derivative into the polypeptide of interest via the orthogonal tRNA-tRNA synthetase pair. The invention also relates to certain amino acids, and to polypeptides comprising same.