The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2018
Filed:
Apr. 13, 2016
Applicant:
Immunogen, Inc., Waltham, MA (US);
Inventors:
Nathan Elliott Fishkin, Weymouth, MA (US);
Michael Louis Miller, Framingham, MA (US);
Wei Li, Acton, MA (US);
Rajeeva Singh, Framingham, MA (US);
Assignee:
IMMUNOGEN, INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 16/30 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); A61K 45/06 (2006.01); A61K 31/5517 (2006.01); A61K 47/54 (2017.01); A61K 47/68 (2017.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); A61K 31/5517 (2013.01); A61K 45/06 (2013.01); A61K 47/545 (2017.08); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); A61K 47/6867 (2017.08); C07D 487/04 (2013.01); C07D 519/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.