The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2018
Filed:
Aug. 28, 2013
Applicant:
Medical & Biological Laboratories Co., Ltd., Nagoya-shi, Aichi, JP;
Inventors:
Kazue Watanabe, Ina, JP;
Shingo Toji, Ina, JP;
Assignee:
MEDICAL & BIOLOGICAL LABORATORIES CO., LTD., Nagoya-shi, Aichi, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C07K 7/08 (2006.01); C07K 16/28 (2006.01); C07K 14/725 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); C07K 14/4748 (2013.01); C07K 14/7051 (2013.01); C07K 16/2803 (2013.01);
Abstract
A method has been developed to efficiently proliferate and culture a CTL specific to WT1 peptides under limiting dilution conditions. Utilizing this method, CTLs capable of recognizing both a state where a wildtype WT1 specific peptide is presented by HLA-A*24:02 and a state where a mutant WT1 specific peptide is presented by HLA-A*24:02 have been successfully obtained.