The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2018
Filed:
Dec. 10, 2014
Applicant:
Cleave Biosciences, Inc., Burlingame, CA (US);
Inventors:
David Wustrow, Los Gatos, CA (US);
Han-Jie Zhou, Foster City, CA (US);
Assignee:
Cleave Biosciences, Inc., Burlingame, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/04 (2006.01); A61K 31/506 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); A61K 31/506 (2013.01);
Abstract
Monocyclic pyrimidine and pyridine compounds having a benzyl amine substituent at the 4 position and a 5:6 bicyclic heteroaryl substituent at the 2 position of the pyrimidine or pyridine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.