IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9868721 B1

PDFFull Text
Date of Patent:
Jan. 16, 2018

Filed:

Oct. 19, 2016

Triazole agonists of the apj receptor

Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Ning Chen, Thousand Oaks, CA (US);

Xiaoqi Chen, Palo Alto, CA (US);

Yinhong Chen, Hayward, CA (US);

Alan C. Cheng, San Francisco, CA (US);

Richard V. Connors, Mesa, AZ (US);

Jeffrey Deignan, San Francisco, CA (US);

Paul John Dransfield, Arlington, MA (US);

Xiaohui Du, Belmont, CA (US);

Zice Fu, Foster City, CA (US);

Julie Anne Heath, Chico, CA (US);

Daniel B. Horne, Natick, MA (US);

Jonathan Houze, Cambridge, MA (US);

Matthew R. Kaller, Ventura, CA (US);

Aarif Yusuf Khakoo, Woodside, CA (US);

David John Kopecky, Studio City, CA (US);

Su-Jen Lai, Boston, MA (US);

Zhihua Ma, Lexington, MA (US);

Lawrence R. McGee, Pacifica, CA (US);

Julio C. Medina, San Carlos, CA (US);

Jeffrey T. Mihalic, San Francisco, CA (US);

Nobuko Nishimura, West Hills, CA (US);

Steven H. Olson, Millbrae, CA (US);

Vatee Pattaropong, Bedford, MA (US);

Gayathri Swaminath, Brisbane, CA (US);

Xiaodong Wang, Johns Creek, GA (US);

Kevin Yang, San Gabriel, CA (US);

Wen-Chen Yeh, Belmont, CA (US);

Mikkel V. Debenedetto, Waltham, MA (US);

Robert P. Farrell, Thousand Oaks, CA (US);

Simon J. Hedley, Thousand Oaks, CA (US);

Ted C. Judd, Granada Hills, CA (US);

Frank Kayser, San Francisco, CA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:

Bernard P. Friedrichsen

Primary Examiner:

Yong L Chu

Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 401/04 (2006.01); C07D 413/04 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/513 (2006.01); A61K 45/06 (2006.01); C07B 57/00 (2006.01); C07B 59/00 (2006.01); C07D 211/54 (2006.01); C07D 213/71 (2006.01); C07D 213/82 (2006.01); C07D 239/26 (2006.01); C07D 239/30 (2006.01); C07D 241/12 (2006.01); C07D 241/24 (2006.01); C07D 249/08 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 401/12 (2006.01); A61K 31/695 (2006.01); C07F 7/08 (2006.01); A61K 31/437 (2006.01); C07C 311/13 (2006.01); C07D 213/61 (2006.01); C07D 239/34 (2006.01); C07D 241/18 (2006.01); C07D 295/16 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/513 (2013.01); A61K 31/695 (2013.01); A61K 45/06 (2013.01); C07B 57/00 (2013.01); C07B 59/002 (2013.01); C07C 311/13 (2013.01); C07D 211/54 (2013.01); C07D 213/61 (2013.01); C07D 213/71 (2013.01); C07D 213/82 (2013.01); C07D 239/26 (2013.01); C07D 239/30 (2013.01); C07D 239/34 (2013.01); C07D 241/12 (2013.01); C07D 241/18 (2013.01); C07D 241/24 (2013.01); C07D 249/08 (2013.01); C07D 295/16 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 405/14 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07F 7/08 (2013.01); C07B 2200/05 (2013.01); C07B 2200/07 (2013.01);
Abstract

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

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