The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2018
Filed:
Dec. 12, 2013
Massachusetts Institute of Technology, Cambridge, MA (US);
The Children's Medical Center Corporation, Boston, MA (US);
Daniel G. Anderson, Sudbury, MA (US);
Hung-Chieh Chou, Cambridge, MA (US);
Michael J. Webber, Cambridge, MA (US);
Benjamin C. Tang, Cambridge, MA (US);
Yair Levi, Halfa, IL;
Yunlong Zhang, Cambridge, MA (US);
Rosemary Lynn Kanasty, Cambridge, MA (US);
Arturo Jose Vegas, Cambridge, MA (US);
Robert S. Langer, Newton, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The Children's Medical Center Corporation, Boston, MA (US);
Abstract
Compounds, compositions, and methods for 'smart' delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.