The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2018
Filed:
Nov. 02, 2016
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Cooper Health System, Camden, NJ (US);
Sri International, Menlo Park, CA (US);
Irving W. Wainer, Washington, DC (US);
Ruin Moaddel, Bel Air, MD (US);
Michel Bernier, Pikesville, MD (US);
Carlos A. Zarate, Germantown, MD (US);
Marc C. Torjman, Southampton, PA (US);
Michael E. Goldberg, Philadelphia, PA (US);
Mary J. Tanga, Los Altos, CA (US);
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH, Washington, DC (US);
COOPER HEALTH SYSTEM, Camden, NJ (US);
SRI INTERNATIONAL, Menlo Park, CA (US);
Abstract
The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain synthetic pain disorder (CRPD) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.