The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 16, 2018

Filed:

Apr. 15, 2016
Applicant:

The University of Hong Kong, Hong Kong, CN;

Inventors:

Wing Fu Lai, Aberdeen, HK;

Ho Cheung Shum, Kowloon, HK;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4164 (2006.01); A61K 9/70 (2006.01); A61K 31/65 (2006.01); A61K 31/5415 (2006.01); A61K 31/58 (2006.01); A61K 47/38 (2006.01); A61K 47/36 (2006.01); A61K 9/00 (2006.01); A61L 26/00 (2006.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01);
U.S. Cl.
CPC ...
A61K 9/7007 (2013.01); A61K 9/0019 (2013.01); A61K 31/4164 (2013.01); A61K 31/5415 (2013.01); A61K 31/58 (2013.01); A61K 31/65 (2013.01); A61K 47/36 (2013.01); A61K 47/38 (2013.01); A61L 26/0023 (2013.01); A61L 26/0066 (2013.01); A61L 31/10 (2013.01); A61L 31/16 (2013.01); A61L 2300/20 (2013.01); A61L 2300/606 (2013.01);
Abstract

Described herein is a drug delivery system, which is based on a novel polymer namely hypromellose-graft-chitosan (HC), useful to deliver a drug to a patient in sustained and controlled release fashion. HC is highly water soluble across the pH range from 1.2 to 10, and has a high pH buffering capacity to provide a pH-stable environment for drug delivery. In addition, the drug delivery system provided herein exhibited a drug loading efficiency of over 90% in all drugs tested, which is 1-2 fold higher than the efficiency attainable by conventional chitosan, and achieved a 2-3 fold longer duration of sustained drug release.


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