The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 09, 2018

Filed:

Sep. 24, 2015
Applicants:

The Board of Trustees of the University of Illinois, Urbana, IL (US);

Northwestern University, Evanston, IL (US);

Inventors:

Scott Thomas Brady, Chicago, IL (US);

Lester I. Binder, Chicago, IL (US);

Gerardo Andres Morfini, Chicago, IL (US);

Nicholas M. Kanaan, Grand Rapids, MI (US);

Nichole E. LaPointe, Santa Barbara, CA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); A61K 39/395 (2006.01); C07K 14/47 (2006.01); G01N 33/50 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 14/4711 (2013.01); G01N 33/5058 (2013.01); A61K 38/00 (2013.01); A61K 39/3955 (2013.01); C07K 2317/32 (2013.01); C07K 2317/34 (2013.01); C07K 2317/76 (2013.01); G01N 2333/4709 (2013.01); G01N 2333/912 (2013.01);
Abstract

The present invention is a composition and method for the prevention and treatment of a tauopathy. The composition of the invention includes N-terminal amino acid residues of the tau protein, which have been identified as being involved in toxic activation of a PP1/GSK3 signaling cascade and inhibition of fast axonal transport in human tauopathies.


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