The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 09, 2018

Filed:

Oct. 01, 2016
Applicants:

Nozer M. Mehta, Randolph, NJ (US);

William Stern, Tenafly, NJ (US);

Amy M. Sturmer, Towaco, NJ (US);

Morten Asser Karsdal, Copenhagen, DK;

Kim Henriksen, Hillerod, DK;

Inventors:

Nozer M. Mehta, Randolph, NJ (US);

William Stern, Tenafly, NJ (US);

Amy M. Sturmer, Towaco, NJ (US);

Morten Asser Karsdal, Copenhagen, DK;

Kim Henriksen, Hillerod, DK;

Assignee:

KeyBioscience AG, Stans, CH;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/23 (2006.01); A61P 3/04 (2006.01); C07K 5/00 (2006.01); C07K 14/585 (2006.01); A61K 31/155 (2006.01); A61K 9/00 (2006.01); A61K 47/18 (2017.01);
U.S. Cl.
CPC ...
C07K 14/585 (2013.01); A61K 9/0053 (2013.01); A61K 31/155 (2013.01); A61K 38/23 (2013.01); A61K 47/183 (2013.01);
Abstract

Provided herein are peptides, that in combination with metformin, are effective for the treatment of type I diabetes, Type II diabetes, metabolic syndrome, or obesity, or of appetite suppression, or for mitigating insulin resistance, or for reducing an undesirably high fasting serum glucose level, or for reducing an undesirably high peak serum glucose level, or for reducing an undesirably high peak serum insulin level, or for reducing an undesirably large response to a glucose tolerance test in synergistic combination with metformin. The peptides are selected from sequences SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 22, SEQ ID NO: 23, and SEQ ID NO: 24.


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