The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2018
Filed:
Jul. 14, 2014
Applicant:
The Cleveland Clinic Foundation, Cleveland, OH (US);
Inventors:
Nima Sharifi, Shaker Hts., OH (US);
Kai-Hsiung Chang, Cleveland, OH (US);
Assignee:
THE CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); A61K 31/56 (2006.01); G01N 33/574 (2006.01); G01N 33/573 (2006.01); G01N 33/53 (2006.01); A61K 31/58 (2006.01); A61K 31/4166 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61K 31/4166 (2013.01); A61K 31/58 (2013.01); G01N 33/57434 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/904 (2013.01); G01N 2800/52 (2013.01);
Abstract
Methods and kits for characterizing a subject having a steroid-dependent disease such as prostate cancer are described. A method of treating a steroid-dependent disease in a subject by obtaining a biological sample from the subject, determining if the HSD3B1(1245C) gene or 3βHSD1(367T) protein is expressed in the biological sample, and providing treatment other than or in addition to steroid ablation to the subject if the HSD3B1(1245C) gene or 3βHSD1(367T) protein is expressed is also described.