The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2018
Filed:
Sep. 06, 2012
Applicants:
Slavica Brnjic, Uppsala, SE;
Padraig D'arcy, Stockholm, SE;
Rolf Larsson, Uppsala, SE;
Stig Linder, Bromma, SE;
Inventors:
Slavica Brnjic, Uppsala, SE;
Padraig D'Arcy, Stockholm, SE;
Rolf Larsson, Uppsala, SE;
Stig Linder, Bromma, SE;
Assignee:
VIVOLUX AB, Uppsala, SE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/37 (2006.01); C12Q 1/34 (2006.01); G01N 33/50 (2006.01); G01N 33/573 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/37 (2013.01); C12Q 1/34 (2013.01); G01N 33/5011 (2013.01); G01N 33/573 (2013.01); G01N 2500/00 (2013.01); G01N 2500/02 (2013.01);
Abstract
A method for screening a compound to determine whether the compound is a proteasome deubiquitinating inhibitor of high specificity comprises contacting the compound with human 19S regulatory particles (19S RP) of 26S proteasome and determining whether the compound inhibits activity of deubiquitinating (DUB) enzymes UCHL5 and USP14; inhibition of UCHL5 and USCP14 activities indicates that the compound is a proteasome deubiquitinating inhibitor of high specificity.