The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2018

Filed:

Dec. 14, 2011
Applicants:

Waander Laurens Van Heerde, Nijmegen, NL;

Richard Hendrik Blaauw, The Netherlands, NL;

Inventors:

Waander Laurens van Heerde, Nijmegen, NL;

Richard Hendrik Blaauw, The Netherlands, NL;

Assignees:

Stichting Katholieke Universiteit, Nijmegen, NL;

Chiralix B.V., Nijmegen, NL;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/66 (2006.01); C12Q 1/37 (2006.01); C12Q 1/56 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/37 (2013.01); C12Q 1/56 (2013.01); C12Q 1/66 (2013.01); G01N 2333/745 (2013.01);
Abstract

The present invention relates to a method for in vitro determining generation of a haemostatis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated via aminoluceferin with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin.


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