The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2018
Filed:
Jan. 14, 2014
Dcb-usa Llc, Wilmington, DE (US);
National Taiwan University, Taipei, TW;
Academia Sinica, Taipei, TW;
Pan-Chyr Yang, Taipei, TW;
Wei-Yun Lai, Taipei, TW;
Konan Peck, Taipei, TW;
Cheng-Ju Chang, Taipei, TW;
Chi-Yuan Chen, Taipei, TW;
Shuenn-Chen Yang, Taipei, TW;
National Taiwan University, Taipei, TW;
ACADEMIA SINICA, Taipei, TW;
Abstract
The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M mutation will knockdown the expression of EGFR T790M mRNA while keeping EGFR wild-type mRNA intact. Hence, these allele-specific DNAzymes against EGFR T790M mutation may overcome T790M-derived TKI resistance accompanied with lower unwanted side effects on normal cells in lung cancer patients.