The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2018

Filed:

Nov. 20, 2014
Applicant:

The United States of America As Represented BY the Secretary, Department of Health, Washington, DC (US);

Inventors:

Richard William Wyatt Childs, Rockville, MD (US);

Yoshiyuki Takahashi, Nagoya, JP;

Sachiko Kajigaya, Rockville, MD (US);

Nanae Harashima, Rockville, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61K 35/17 (2015.01); A61K 39/21 (2006.01); C07K 14/005 (2006.01); A61K 39/12 (2006.01); A61K 35/12 (2015.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0638 (2013.01); A61K 35/12 (2013.01); A61K 35/17 (2013.01); A61K 39/12 (2013.01); A61K 39/21 (2013.01); C07K 14/005 (2013.01); A61K 39/00 (2013.01); A61K 2039/585 (2013.01); C12N 2740/10022 (2013.01); C12N 2740/10034 (2013.01);
Abstract

Compositions and methods are provided for preventing or treating neoplastic disease in a mammalian subject. A composition is provided which comprises an enriched immune cell population reactive to a human endogenous retrovirus type E antigen on a tumor cell. A method of treating a neoplastic disease in a mammalian subject is provided which comprises administering to a mammalian subject a composition comprising an enriched immune cell population reactive to a human endogenous retrovirus type E antigen, in an amount effective to reduce or eliminate the neoplastic disease or to prevent its occurrence or recurrence.


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