The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2018
Filed:
Feb. 01, 2017
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Joseph Edward Shultz, Binningen, CH;
Roger Hart, Needham, MA (US);
Ronald Nixon Keener, III, Newbury Park, CA (US);
Assignee:
Amgen Inc., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); C07K 1/113 (2006.01); C07K 1/14 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C07K 1/1136 (2013.01); C07K 1/1133 (2013.01); C07K 1/14 (2013.01); C07K 14/00 (2013.01); C07K 16/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
Shultz, Joseph. (2018). Refolding proteins using a chemically controlled redox state (U.S. Patent No. 9856287). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9856287
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile