The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2018

Filed:

Feb. 20, 2014
Applicant:

Cancer Therapeutics Crc Pty Ltd, Bundoora, Victoria, AU;

Inventors:

Paul Anthony Stupple, Bundoora, AU;

Scott Raymond Walker, Parkville, AU;

Jo-Anne Pinson, Parkville, AU;

Helen Rachel Lagiakos, Parkville, AU;

Gillian Elizabeth Lunniss, Parkville, AU;

Ian Peter Holmes, Bundoora, AU;

Alexandra Elizabeth Stupple, Parkville, AU;

Ylva Elisabet Bergman, Parkville, AU;

Richard Charles Foitzik, Parkville, AU;

Wilhelmus Johannes Antonius Kersten, Bundoora, AU;

Michelle Ang Camerino, Parkville, AU;

Assignee:

Cancer Therapeutics CRC Pty Ltd, Bundoora, Victoria, AU;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/00 (2006.01); C07D 401/00 (2006.01); C07D 513/02 (2006.01); C07D 471/04 (2006.01); C07D 235/18 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 235/18 (2013.01); C07D 519/00 (2013.01);
Abstract

Substituted benzimidazole and 3H-imidazo[4,5-b]pyridines or formula I: where X and Y respectively are selected from: (i) N and N; and (ii) N and CR; Ais selected from: a Cheteroarylene group, containing 2 or 3 ring heteroatoms, where the bonds to L1 and the core are β to one another; Lis selected from: (i)—O—CH—; (ii)—CH—O—; (iii)—C(═O)—NH—; (iv)—CH(OH)—; (v)—CH—NH—C(═O)—; (vi)—S—CH—; (vii)—CH—S—; (viii)—CH—; and (ix)—CH(CH)—O—; A1 is phenyl, optionally substituted by F or CF; their use as pharmaceuticals, and in particular, in treating cancer and hemoglobinopathies.


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