The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 02, 2018

Filed:

Oct. 08, 2013
Applicant:

Ascendis Pharma A/s, Hellerup, DK;

Inventors:

Harald Rau, Dossenheim, DE;

Tobias Voigt, Heidelberg, DE;

Burkhardt Laufer, Dossenheim, DE;

Nicola Bisek, Heidelberg, DE;

Franziska Hahn, Stuttgart, DE;

Thomas Knappe, Heidelberg, DE;

Assignee:

Ascendis Pharma A/S, Hellerup, DK;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); C08G 83/00 (2006.01); C08J 3/075 (2006.01); C08G 65/332 (2006.01); A61K 31/4188 (2006.01); C08G 69/44 (2006.01); C08G 69/48 (2006.01); C08G 65/333 (2006.01); C08F 2/22 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48215 (2013.01); A61K 31/4188 (2013.01); A61K 47/48146 (2013.01); A61K 47/48192 (2013.01); A61K 47/48315 (2013.01); A61K 47/48546 (2013.01); A61K 47/48784 (2013.01); C08G 65/332 (2013.01); C08G 65/3322 (2013.01); C08G 65/33337 (2013.01); C08G 65/33389 (2013.01); C08G 69/44 (2013.01); C08G 69/48 (2013.01); C08G 83/004 (2013.01); C08G 83/006 (2013.01); C08J 3/075 (2013.01); C08F 2/22 (2013.01); C08G 2210/00 (2013.01); C08J 2300/202 (2013.01); C08J 2371/02 (2013.01); C08J 2400/202 (2013.01); C08J 2471/02 (2013.01); C08L 2203/02 (2013.01);
Abstract

The present invention relates to a process for the preparation of a hydrogel and to a hydrogel obtainable by said process. The present invention further relates to a process for the preparation of a hydrogel-spacer conjugate, to a hydrogel-spacer conjugate obtainable by said process, to a process for the preparation of a carrier-linked prodrug and to carrier-linked prodrugs obtainable by said process, in particular to carrier-linked prodrugs that provide for a controlled or sustained release of a drug from a carrier. In addition, the invention relates to the use of the hydrogel for the preparation of a carrier-linked prodrug.


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