The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2018
Filed:
Sep. 30, 2014
Los Alamos National Security, Llc, Los Alamos, NM (US);
Duke University, Durham, NC (US);
Dana-farber Cancer Institute, Inc.;
Bette T. M. Korber, Los Alamos, NM (US);
S. Gnanakaran, Los Alamos, NM (US);
Simon Perkins, Boulder, CO (US);
Joseph Sodroski, Boston, MA (US);
Barton Haynes, Durham, NC (US);
Los Alamos National Security, LLC, Los Alamos, NM (US);
Dana-Farber Cancer Institute, Brookline, MA (US);
Duke University, Durham, NC (US);
Abstract
Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.