The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2018
Filed:
Nov. 28, 2013
Applicant:
Leo Pharma A/s, Ballerup, DK;
Inventor:
Paola Lovato, Ballerup, DK;
Assignee:
LEO PHARMA A/S, Ballerup, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/59 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/593 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/59 (2013.01); A61K 31/44 (2013.01); A61K 31/4427 (2013.01); A61K 31/593 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention relates to a method of inhibiting the upregulation of the expression of the proinflammatory cytokine interleukin-22 (IL-22) in activated and differentiated human T-cells, said upregulation being induced by administration of a therapeutically effective amount of a phosphodiesterase 4 (PDE4) inhibitor. The method comprises administering, either sequentially to or simultaneously with the administration of the PDE4 inhibitor, a vitamin D receptor agonist in an amount sufficient to inhibit the upregulation of IL-22 expression.