The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2018
Filed:
May. 26, 2017
King Saud University, Riyadh, SA;
Nagy Mahmoud Hassan Khalifa, Riyadh, SA;
Mohamed A. Al-Omar, Riyadh, SA;
Abd El-Galil E. Amr, Riyadh, SA;
KING SAUD UNIVERSITY, Riyadh, SA;
Abstract
The substituted naphthyridinyl hydrazine compounds as anti-liver cancer agents are anti-liver cancer agents that inhibit proliferative pathways of cancer cells, thereby exhibiting potent in vitro and in vivo anticancer activity. The compounds have the formula: wherein Rand Reach are selected independently from hydrogen, mercapto, and C-C-alkyl, preferably methyl, ethyl, propyl, isopropyl or halogen; Rand Reach are selected independently from hydrogen, alkyl or halogen; and Ris selected from substituted or unsubstituted aryl, more preferably from substituted phenyl, naphthyl, and substituted or unsubstituted heteroaryl, more preferably from furyl, pyrrolyl, thienyl, imidazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, benzothiazolyl, oxadiazolyl or sugar moities. These agents exert their action through topoisomerase II inhibition.