The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2017
Filed:
Mar. 04, 2014
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Chun-Jen Lin, Houston, TX (US);
Guang Peng, Houston, TX (US);
Shiaw-Yih Lin, Pearland, TX (US);
Gordon B. Mills, Houston, TX (US);
Assignee:
Board of Regents, The University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/424 (2006.01); C12Q 1/68 (2006.01); G01N 33/574 (2006.01); A61K 31/167 (2006.01); A61K 31/436 (2006.01); A61K 31/502 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61K 31/167 (2013.01); A61K 31/436 (2013.01); A61K 31/502 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); G01N 33/57415 (2013.01); G01N 33/57423 (2013.01); G01N 33/57442 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); G01N 2800/52 (2013.01);
Abstract
Methods for identifying and treating cancers that are homologous recombination (HR)-repair defective. In some aspects, HR defective cancers are treated with a PARP inhibitor therapy. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided.