The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2017
Filed:
Jun. 05, 2015
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
R. John Collier, Wellesley, MA (US);
Bradley L. Pentelute, Cambridge, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12N 9/52 (2006.01); C07K 14/195 (2006.01); C07K 16/46 (2006.01); C12N 9/10 (2006.01); C12N 9/24 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/52 (2013.01); C07K 14/195 (2013.01); C07K 16/46 (2013.01); C12N 9/1048 (2013.01); C12N 9/2497 (2013.01); A61K 38/00 (2013.01); C07K 2319/10 (2013.01); C07K 2319/50 (2013.01); C07K 2319/55 (2013.01);
Abstract
The invention provides compositions and methods for delivering a bioactive moiety comprising at least one non-natural component into a cell cytosol of a eukaryotic cell. The bioactive moiety is linked to an A component of a bacterial toxin, a functional wild-type or modified fragment thereof, or an A component surrogate or mimetic. For delivery, the cell is contacted with the linked bioactive moiety and a corresponding B component of the bacterial toxin or a functional fragment thereof.