The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2017
Filed:
Oct. 08, 2015
Applicant:
University of Maryland, Baltimore, Baltimore, MD (US);
Inventor:
Lai-Xi Wang, Ellicott City, MD (US);
Assignee:
University of Maryland, Baltimore, Baltimore, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/40 (2006.01); A61K 39/395 (2006.01); C07K 16/00 (2006.01); C12P 21/08 (2006.01); C12N 9/24 (2006.01); C12P 21/00 (2006.01); C07K 16/28 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C12N 9/2402 (2013.01); A61K 47/6849 (2017.08); C07K 16/00 (2013.01); C07K 16/2887 (2013.01); C12P 21/005 (2013.01); C12Y 302/01096 (2013.01); C07K 2317/41 (2013.01);
Abstract
The present invention provides for recombinant Endo-D and selected mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor by transglycosylation. Such recombinant Endo-D and selected mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain.