The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2017
Filed:
Apr. 30, 2014
Applicant:
Engene, Inc., Vancouver, CA;
Inventors:
Eric Hsu, Vancouver, CA;
Carlos Fleet, Vancouver, CA;
Anthony Cheung, Vancouver, CA;
Jun Gao, Coquitlam, CA;
Assignee:
ENGENE, INC., Montreal, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08B 37/00 (2006.01); C07H 17/02 (2006.01); A61K 31/7088 (2006.01); C12N 15/87 (2006.01);
U.S. Cl.
CPC ...
C08B 37/0063 (2013.01); A61K 31/7088 (2013.01); C07H 17/02 (2013.01); C12N 15/87 (2013.01); Y10T 428/2982 (2015.01);
Abstract
The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provides are methods for altering the diameter of chitosan-nucleic acid polyplexes.