The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2017
Filed:
Oct. 26, 2015
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Alexander Pasternak, Kenilworth, NJ (US);
Fa-xiang Ding, Kenilworth, NJ (US);
Shuzhi Dong, Kenilworth, NJ (US);
Jinlong Jiang, Kenilworth, NJ (US);
Haifeng Tang, Kenilworth, NJ (US);
Xin Gu, Kenilworth, NJ (US);
Reynalda K. Dejesus, Kenilworth, NJ (US);
Jessica Frie, West Point, PA (US);
Qinghong Fu, Plainsboro, NJ (US);
Takao Suzuki, Shanghai, CN;
Zhifa Pu, Shanghai, CN;
Alexander Pasternak, Princeton, NJ (US);
Fa-Xiang Ding, Staten Island, NY (US);
Shuzhi Dong, Plainsboro, NJ (US);
Jinlong Jiang, Scotch Plains, NJ (US);
Haifeng Tang, Metuchen, NJ (US);
Xin Gu, Scotch Plains, NJ (US);
Reynalda K. DeJesus, East Brunswick, NJ (US);
Jessica Frie, Harleysville, PA (US);
Qinghong Fu, Plainsboro, NJ (US);
Takao Suzuki, Shanghai, CN;
Zhifa Pu, Shanghai, CN;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.