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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9850236 B1

PDFFull Text
Date of Patent:
Dec. 26, 2017

Filed:

Oct. 30, 2015

Trifluoromethyl alcohols as modulators of rorγt

Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Steven Goldberg, Carlsbad, CA (US);

Hariharan Venkatesan, San Diego, CA (US);

Virginia Tanis, Vista, CA (US);

Olaf Kinzel, Heidelberg, DE;

Christian Gege, Ehingen, DE;

Christoph Steeneck, Heidelberg, DE;

Gerald Kleymann, Bad Salzuflen, DE;

Thomas Hoffmann, Speyer, DE;

Anne M. Fourie, San Diego, CA (US);

Xiaohua Xue, San Diego, CA (US);

Assignee:

Janssen Pharmaceutica NV, Beerse, BE;

Attorney:

Yuriy P. Stercho

Primary Examiner:

Kathrien Cruz

Assistant Examiner:

Janet L Coppins

Int. Cl.
CPC ...
A61K 31/426 (2006.01); C07D 277/56 (2006.01); C07D 417/06 (2006.01); A61K 31/454 (2006.01); A61K 45/06 (2006.01); C07D 487/08 (2006.01); A61K 31/427 (2006.01); C07D 495/10 (2006.01); C07D 417/14 (2006.01); A61K 31/4709 (2006.01); A61K 31/541 (2006.01); A61K 31/4439 (2006.01);
U.S. Cl.
CPC ...
C07D 417/06 (2013.01); A61K 31/426 (2013.01); A61K 31/427 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/4709 (2013.01); A61K 31/541 (2013.01); A61K 45/06 (2013.01); C07D 277/56 (2013.01); C07D 417/14 (2013.01); C07D 487/08 (2013.01); C07D 495/10 (2013.01);
Abstract

The present invention comprises compounds of Formula I. wherein:X, A, A, A, A, R, R, and Rare defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

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