S1p and/or atx modulating agents

Abstract

Compounds of formula (I) wherein: X is —O—, —S(O)—, —CH—, or —NR—, wherein r is 0, 1, or 2; X, X, and Xare each independently CRor N; one of Xor Xis C and is attached by a single bond to -L-, and the other is CRor N, provided that no more than three of X, X, X, X or Xare N; Ring A is monocyclic Cscycloalkyl or a 5- to 6-membered monocyclic heterocyclyl comprising from 1 to 5 heteroatoms independently selected from N, S, or O; wherein Ring A is further optionally substituted with from 1 to 3 R; provided that Ring A is not morpholinyl, thiomorpholinyl or tetrahydro-2H-pyranyl; L is a bond, —O—, —NR—, —S(O)—, —CH—, or —C(O)—, wherein n is 0, 1, or 2; 1 2 Lis an Calkylene, Ccycloalkylene, —CH-L-, or a 3- to 8-membered heterocyclylene comprising 1 to 5; Ris Calkyl or a monocyclic Ccycloalkyl; wherein said Ccycloalkyl is substituted with at least one Rand may be optionally substituted with from 1 to 5 additional Rsubstituents, wherein Rfor each occurrence is independently selected; and Ris —C(O)OR, —C(O)N(R)—S(O)R, —S(O)OR, —C(O)NHC(O)R, —Si(O)OH, —B(OH), —N(R)S(O)R, —S(O)N(R), —O—P(O)(OR), or —P(O)(OR), —CN, —S(O)NHC(O)R, —C(O)NHS(O)R3, —C(O)NHOH, —C(O)NHCN, —CH(CF)OH, —C(CF)OH, or a selected heteroaryl or heterocyclyl; and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).