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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9849190 B1

PDFFull Text
Date of Patent:
Dec. 26, 2017

Filed:

Aug. 11, 2016

Peptide having cancer selective translocation function and use thereof

Applicants:

Snu R&db Foundation, Seoul, KR;

Nano Intelligent Biomedical Engineering Corporation Co. Ltd, Seoul, KR;

Inventors:

Yoon Jeong Park, Seoul, KR;

Chong-Pyoung Chung, Seoul, KR;

Jin Sook Suh, Seoul, KR;

Yoon Jung Choi, Gyeonggi-do, KR;

Assignees:

SNU R&DB FOUNDATION, Seoul, KR;

NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO, LTD., Seoul, KR;

Attorneys:

Hultquist, PLLC

Steven J. Hultquist

Primary Examiner:

Julie Ha

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 47/64 (2017.01); C07K 14/47 (2006.01); C07K 7/08 (2006.01); C12Q 1/26 (2006.01); C12Q 1/58 (2006.01); C12Q 1/66 (2006.01); A61K 47/48 (2006.01); G01N 33/574 (2006.01); A61K 31/704 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48246 (2013.01); A61K 31/704 (2013.01); A61K 47/64 (2017.08); A61K 49/0056 (2013.01); C07K 7/08 (2013.01); C07K 14/47 (2013.01); C12Q 1/26 (2013.01); C12Q 1/58 (2013.01); C12Q 1/66 (2013.01); C12Y 301/13 (2013.01); G01N 33/574 (2013.01); A61K 38/00 (2013.01); C07K 2319/10 (2013.01);
Abstract

A method of treating breast cancer is described, in which a peptide having cancer selective translocation function-doxoribicin conjugate is administered. The conjugate includes doxorubicin chemically linked to the N-terminus or C-terminus of a VEGF-binding protein transduction domain (VPTD) peptide represented as SEQ ID NO:, wherein the VPTD peptide and doxorubicin are linked to each other by a disulfide bond, and wherein the VPTD peptide binds specifically to vascular endothelial growth factor (VEGF) in tumor cells or tumor tissues.

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