The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2017
Filed:
Dec. 16, 2015
Applicant:
The University of British Columbia, Vancouver, CA;
Inventor:
Neil R. Cashman, Vancouver, CA;
Assignee:
The University of British Columbia, Vancouver, CA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); G01N 33/68 (2006.01); C07K 7/06 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0005 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); C07K 7/06 (2013.01); C07K 14/4711 (2013.01); C07K 16/18 (2013.01); G01N 33/6896 (2013.01); A61K 39/00 (2013.01); A61K 2039/58 (2013.01); C07K 2317/34 (2013.01); G01N 2333/4709 (2013.01);
Abstract
A novel constrained peptide epitope derived from Aβ, related antibody compositions and methods of use. An isolated antibody that specifically binds to a cyclic peptide comprising the conformational epitope corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric Aβ is described. An antigenic peptide comprising an epitope having a constrained cyclic configuration, corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric Aβ is also described. Methods of treating, preventing, and diagnosing Alzheimer's disease are also described.