The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2017
Filed:
Feb. 27, 2013
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Venkata Battula, Houston, TX (US);
Michael Andreeff, Houston, TX (US);
Sendurai A. Mani, Houston, TX (US);
Tapasree Roy Sarkar, Houston, TX (US);
Assignee:
Board of Regents, The University of Texas Systems, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); A61K 31/513 (2006.01); A61K 31/4192 (2006.01); A61K 39/395 (2006.01); C07K 16/30 (2006.01); A61K 31/4196 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57492 (2013.01); A61K 31/4192 (2013.01); A61K 31/4196 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); C07K 16/3084 (2013.01); G01N 33/57407 (2013.01); G01N 33/57415 (2013.01); A61K 2039/505 (2013.01); G01N 2405/10 (2013.01); G01N 2800/54 (2013.01); G01N 2800/7028 (2013.01);
Abstract
Methods for determining the presence of cancer stem cells by detecting GD2 expression. Also provided are methods for reducing proliferation of cancer stem cells by contacting the cells with a GD2 targeting agent, such as an anti-GD2 antibody or a GD3 synthase inhibitor. GD3 synthase inhibitor compounds are also provided.