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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9846156 B1

PDFFull Text
Date of Patent:
Dec. 19, 2017

Filed:

Oct. 21, 2016

Method of treatment employing cardiac glycoside

Applicant:

Phoenix Biotechnology, Inc., San Antonio, TX (US);

Inventors:

Otis C. Addington, San Antonio, TX (US);

Peiying Yang, Sugarland, TX (US);

Robert A. Newman, Surry, ME (US);

Assignee:

Phoenix Biotechnology, Inc.;

Attorneys:

Rick Matos

Innovar, L.L.C.

Primary Examiner:

Shan Elahi

Int. Cl.
CPC ...
G01N 33/573 (2006.01); C12Q 1/68 (2006.01); G06F 19/12 (2011.01); A61K 31/58 (2006.01); A61K 31/704 (2006.01); G01N 33/574 (2006.01); A61K 31/7048 (2006.01); A61K 45/06 (2006.01); G01N 33/68 (2006.01); A61K 31/513 (2006.01); A61K 31/7008 (2006.01); A61K 36/24 (2006.01);
U.S. Cl.
CPC ...
G01N 33/573 (2013.01); A61K 31/513 (2013.01); A61K 31/58 (2013.01); A61K 31/704 (2013.01); A61K 31/7008 (2013.01); A61K 31/7048 (2013.01); A61K 36/24 (2013.01); A61K 45/06 (2013.01); C12Q 1/6883 (2013.01); C12Y 306/01003 (2013.01); G01N 33/574 (2013.01); G01N 33/6872 (2013.01); G06F 19/12 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/914 (2013.01); G01N 2800/52 (2013.01); G01N 2800/7023 (2013.01); G01N 2800/7028 (2013.01);
Abstract

A method of treatment employing cardiac glycoside is disclosed. A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the α subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside.

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