The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 19, 2017

Filed:

Aug. 17, 2015
Applicant:

Quanterix Corporation, Lexington, MA (US);

Inventors:

David M. Rissin, Somerville, MA (US);

David Fournier, Northborough, MA (US);

David C. Duffy, Arlington, MA (US);

Assignee:

Quanterix Corporation, Lexington, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); G01N 33/573 (2006.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
G01N 33/573 (2013.01); G01N 21/6428 (2013.01); G01N 21/6452 (2013.01); G01N 33/54313 (2013.01); G01N 33/54366 (2013.01); G01N 2201/062 (2013.01); G01N 2333/924 (2013.01);
Abstract

Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.


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