The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2017
Filed:
Aug. 13, 2014
Sanofi, Paris, FR;
Alla Pritsker, Bridgewater, NJ (US);
Patrick Grailhe, Paris, FR;
Alexey Rak, Paris, FR;
Magali Mathieu, Paris, FR;
Christopher Ryan Morgan, Bridgewater, NJ (US);
Nicolas Baurin, Paris, FR;
Bruno Poirier, Paris, FR;
Cyril Daveu, Paris, FR;
Francis Duffieux, Paris, FR;
Han Li, Yardley, PA (US);
Dorothea Kominos, Millington, NJ (US);
Philip Janiak, Paris, FR;
Sanofi, Paris, FR;
Abstract
The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1), The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.