The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 19, 2017

Filed:

Mar. 30, 2005
Applicants:

Mette Grønborg, Copenhagen, DK;

Philip Kusk, Lynge, DK;

Nikolaj Blom, Copenhagen, DK;

Thomas Nordahl Petersen, Copenhagen, DK;

Teit E. Johansen, Hørsholm, DK;

Søren Brunak, Hellerup, DK;

Lars U. Wahlberg, Asnæs, DK;

Inventors:

Mette Grønborg, Copenhagen, DK;

Philip Kusk, Lynge, DK;

Nikolaj Blom, Copenhagen, DK;

Thomas Nordahl Petersen, Copenhagen, DK;

Teit E. Johansen, Hørsholm, DK;

Søren Brunak, Hellerup, DK;

Lars U. Wahlberg, Asnæs, DK;

Assignee:

HOBA THERAPEUTICS APS, Copenhagen, DK;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); C07K 14/475 (2006.01); A01K 67/027 (2006.01); A61K 38/17 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/475 (2013.01); A01K 67/027 (2013.01); A61K 38/185 (2013.01); A01K 2207/05 (2013.01); A01K 2207/20 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0356 (2013.01); A61K 38/00 (2013.01); A61K 38/17 (2013.01); C12N 2799/027 (2013.01);
Abstract

The present invention relates to the field of therapeutic use of proteins, genes and cells. More specifically the invention relates to therapy based on the biological function of a secreted therapeutic protein, NsG33, in particular for the treatment of disorders of the nervous system. NsG33 is a nerve survival and growth factor with antiapoptotic effects on a cell line with neuronal potential and with neuroprotective and/or neurogenesis effects on a neural precursor cell line and on primary striatal cultures. The invention also relates to novel bioactive NsG33 polypeptide fragments and the corresponding encoding DNA sequences.


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