IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9845310 B1

PDFFull Text
Date of Patent:
Dec. 19, 2017

Filed:

Oct. 20, 2016

Intermediates for preparing triazole agonists of the apj receptor

Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Ning Chen, Thousand Oaks, CA (US);

Xiaoqi Chen, Palo Alto, CA (US);

Alan C. Cheng, San Francisco, CA (US);

Richard V. Connors, Mesa, AZ (US);

Jeffrey Deignan, San Francisco, CA (US);

Paul John Dransfield, Arlington, MA (US);

Xiaohui Du, Belmont, CA (US);

Zice Fu, Foster City, CA (US);

Julie Anne Heath, Chico, CA (US);

Daniel B. Horne, Natick, MA (US);

Jonathan Houze, Cambridge, MA (US);

Matthew R. Kaller, Ventura, CA (US);

David John Kopecky, Studio City, CA (US);

Su-Jen Lai, Boston, MA (US);

Zhihua Ma, Lexington, MA (US);

Lawrence R. McGee, Pacifica, CA (US);

Julio C. Medina, San Carlos, CA (US);

Jeffrey T. Mihalic, San Francisco, CA (US);

Nobuko Nishimura, West Hills, CA (US);

Steven H. Olson, Millbrae, CA (US);

Vatee Pattaropong, Bedford, MA (US);

Xiaodong Wang, Johns Creek, GA (US);

Kevin Yang, San Gabriel, CA (US);

Mikkel V. Debenedetto, Waltham, MA (US);

Simon J. Hedley, Thousand Oaks, CA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:

Bernard P. Friedrichsen

Primary Examiner:

Yong Chu

Int. Cl.
CPC ...
A61K 31/4439 (2006.01); C07D 239/30 (2006.01); C07D 401/14 (2006.01); C07D 401/04 (2006.01); C07D 413/04 (2006.01); A61K 31/444 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/513 (2006.01); A61K 45/06 (2006.01); C07B 57/00 (2006.01); C07B 59/00 (2006.01); C07D 211/54 (2006.01); C07D 213/71 (2006.01); C07D 213/82 (2006.01); C07D 239/26 (2006.01); C07D 241/12 (2006.01); C07D 241/24 (2006.01); C07D 249/08 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 401/12 (2006.01); A61K 31/695 (2006.01); C07F 7/08 (2006.01); A61K 31/437 (2006.01); C07C 311/13 (2006.01); C07D 213/61 (2006.01); C07D 239/34 (2006.01); C07D 241/18 (2006.01); C07D 295/16 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/513 (2013.01); A61K 31/695 (2013.01); A61K 45/06 (2013.01); C07B 57/00 (2013.01); C07B 59/002 (2013.01); C07C 311/13 (2013.01); C07D 211/54 (2013.01); C07D 213/61 (2013.01); C07D 213/71 (2013.01); C07D 213/82 (2013.01); C07D 239/26 (2013.01); C07D 239/30 (2013.01); C07D 239/34 (2013.01); C07D 241/12 (2013.01); C07D 241/18 (2013.01); C07D 241/24 (2013.01); C07D 249/08 (2013.01); C07D 295/16 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 405/14 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07F 7/08 (2013.01); C07B 2200/05 (2013.01); C07B 2200/07 (2013.01);
Abstract

Compounds of Formula VII, salts thereof, tautomers thereof, and salts of the tautomers are useful intermediates in the synthesis of agonists of the APJ Receptor. Compounds of Formula VII have the following structure: where the definitions of the variables are provided herein.

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