The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 19, 2017

Filed:

Dec. 09, 2013
Applicants:

The Cleveland Clinic Foundation, Cleveland, OH (US);

Juventas Therapeutics, Inc., Cleveland, OH (US);

Inventors:

Marc S. Penn, Beachwood, OH (US);

Rahul Aras, Broadview Heights, OH (US);

Joseph Pastore, Mentor, OH (US);

Timothy J. Miller, Cleveland Heights, OH (US);

Assignees:

The Cleveland Clinic, Cleveland, OH (US);

Juventas Therapeutics, Inc., Cleveland, OH (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); A61K 48/00 (2006.01); C07H 21/00 (2006.01); A61K 38/19 (2006.01); A61K 9/00 (2006.01); A61K 31/711 (2006.01); C07K 14/52 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/19 (2013.01); A61K 9/0019 (2013.01); A61K 31/711 (2013.01); A61K 48/005 (2013.01); C07K 14/521 (2013.01); A61K 38/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/09 (2013.01);
Abstract

A method of treating a cardiomyopathy in a subject includes administering directly to or expressing locally in a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification.


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