The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2017
Filed:
Aug. 06, 2013
Applicants:
Life & Brain Gmbh, Bonn, DE;
Rheinische Friedrich-wilhelms Universität, Bonn, DE;
Inventors:
Assignees:
LIFE & BRAIN GMBH, Bonn, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/167 (2006.01); A61K 45/06 (2006.01); A61K 31/4188 (2006.01); A61K 31/609 (2006.01); G01N 33/574 (2006.01); C07C 235/64 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
A61K 31/167 (2013.01); A61K 31/4188 (2013.01); A61K 31/609 (2013.01); A61K 45/06 (2013.01); C07C 235/64 (2013.01); C12Q 1/6883 (2013.01); G01N 33/57484 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/16 (2013.01); G01N 2800/52 (2013.01);
Abstract
The present invention relates to novel therapeutic uses of niclosamide for the treatment of cancer. In particular, a combination of niclosamide or one of its derivatives with an alkylating agent is provided for the treatment of solid tumors. Moreover, niclosamide or one of its derivatives can be used for the treatment of solid tumors characterized by underexpression of NFKBIA. Finally, the invention relates to diagnostic methods for determining whether treatment with niclosamide alone or in combination with an alkylating agent is suitable for a cancer patient.