The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2017
Filed:
Nov. 11, 2016
Rosalind Franklin University of Medicine and Science, North Chicago, IL (US);
The Mclean Hospital Corporation, Belmont, MA (US);
Michelle L. Hastings, North Chicago, IL (US);
Ole Isacson, Belmont, MA (US);
Joanna A. Korecka-Roet, Belmont, MA (US);
Rosalind Franklin University of Medicine and Science, North Chicago, IL (US);
The McLean Hospital Corporation, Belmont, MA (US);
Abstract
The present disclosure relates generally to compounds comprising oligonucleotides complementary to a Leucine-Rich-Repeat-Kinase (LRRK2) RNA transcript. Certain such compounds are useful for hybridizing to a LRRK2 RNA transcript, including but not limited to a LRRK2 RNA transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the LRRK2 transcript. In certain embodiments, such compounds are used to treat one or more symptoms associated with Parkinson's disease.