The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2017
Filed:
Jun. 29, 2015
Kodiak Sciences Inc., Palo Alto, CA (US);
D. Victor Perlroth, Palo Alto, CA (US);
Stephen A. Charles, Ravenna, OH (US);
James Aggen, Westwood, MA (US);
Didler Benoit, San Jose, CA (US);
Wayne To, San Mateo, CA (US);
Lidia Mosyak, Newton, MA (US);
Laura Lin, Weston, MA (US);
Justin Cohen, Quincy, MA (US);
Tetsuya Ishino, Boston, MA (US);
William Somers, Lexington, MA (US);
KODIAK SCIENCES INC., Palo Alto, CA (US);
Abstract
The invention provides a dual VEGF/PDGF antagonist comprising a VEGF antagonist linked to a PDGF antagonist. The VEGF antagonist is an antibody to a VEGF or VEGFR or is a VEGFR extracellular trap segment (i.e., a segment from the extracellular region of one or more VEGFR receptors that inhibits binding of at least one VEGFR to at least one VEGF). The PDGF antagonist is an antibody to a PDGF or PDGFR or is a PDGFR extracellular trap segment (i.e., segment from the extracellular region of one or more PDGFRs, which inhibits binding of at least one PDGFR and at least one PDGF). The dual antagonist is preferably conjugated to a half-life extending moiety, such as a HEMA-PC polymer. The dual antagonist is particularly useful for treating wet aged related macular degeneration.