The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2017
Filed:
Dec. 21, 2011
Andrés Avelino Trabanco-suárez, Toledo, ES;
Francisca Delgado-jiménez, Toledo, ES;
Juan Antonio Vega Ramiro, Toledo, ES;
Gary John Tresadern, Toledo, ES;
Henricus Jacobus Maria Gijsen, Beerse, BE;
Daniel Oehlrich, Beerse, BE;
Andrés Avelino Trabanco-Suárez, Toledo, ES;
Francisca Delgado-Jiménez, Toledo, ES;
Juan Antonio Vega Ramiro, Toledo, ES;
Gary John Tresadern, Toledo, ES;
Henricus Jacobus Maria Gijsen, Beerse, BE;
Daniel Oehlrich, Beerse, BE;
Janssen Pharmaceutica, NV, Beerse, BE;
Abstract
The present invention relates to novel 5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine inhibitors of beta-secretase, having the structure shown in Formula (I) wherein R, R, R, R, X, X, X, X, L and Ar are defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, cerebrovascular amyloid angiopathy, multi-infarct dementia, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.