The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 12, 2017

Filed:

Jul. 29, 2014
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Msd R&d (China) Co., Ltd., Shanghai, CN;

Inventors:

Peter D. Williams, Harleysville, PA (US);

John A. McCauley, Maple Glen, PA (US);

David Jonathan Bennett, Winchester, MA (US);

Christopher J. Bungard, Lansdale, PA (US);

Lehua Chang, Ramsey, NJ (US);

Michael P. Dwyer, Scotch Plains, NJ (US);

M. Katharine Holloway, Lansdale, PA (US);

Kartik M. Keertikar, East Windsor, NJ (US);

H. Marie Loughran, Perkasie, PA (US);

Jessie J. Manikowski, Worcester, PA (US);

Gregori J. Morriello, Randolph, NJ (US);

Dong-Ming Shen, Edison, NJ (US);

Edward C. Sherer, Hillsborough, NJ (US);

Jurgen Schultz, Scotland, GB;

Sherman T. Waddell, Westfield, NJ (US);

Catherine M. Wiscount, Allentown, PA (US);

Nicolas Zorn, Durmenach, FR;

Xin-Jie Chu, Shanghai, CN;

Satyanarayana Tummanapalli, The Galen, SG;

Vijayasaradhi Sivalenka, The Galen, SG;

Bin Hu, Shanghai, CN;

Tao Ji, Shanghai, CN;

Bin Zhong, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 241/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01);
Abstract

The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.


Find Patent Forward Citations

Loading…