The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 12, 2017

Filed:

May. 04, 2015
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Haifeng Tang, Metuchen, NJ (US);

Shu-Wei Yang, Edison, NJ (US);

Mihir Mandal, Westfield, NJ (US);

Jing Su, Scotch Plains, NJ (US);

Guoqing Li, Belle Mead, NJ (US);

Weidong Pan, Hillsborough, NJ (US);

Haiqun Tang, Belle Mead, NJ (US);

Reynalda DeJesus, East Brunswick, NJ (US);

Jianping Pan, Monmouth Junction, NJ (US);

William Hagmann, Westfield, NJ (US);

Fa-Xiang Ding, Staten Island, NY (US);

Li Xiao, Cranbury, NJ (US);

Alexander Pasternak, Princeton, NJ (US);

Yuhua Huang, Westfield, NJ (US);

Shuzhi Dong, Plainsboro, NJ (US);

Dexi Yang, Livingston, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/407 (2006.01); A61K 31/41 (2006.01); A61K 31/427 (2006.01); A61K 31/43 (2006.01); A61K 31/44 (2006.01); A61K 31/496 (2006.01); A61K 31/546 (2006.01);
U.S. Cl.
CPC ...
A61K 31/546 (2013.01); A61K 31/407 (2013.01); A61K 31/41 (2013.01); A61K 31/427 (2013.01); A61K 31/43 (2013.01); A61K 31/44 (2013.01); A61K 31/496 (2013.01); A61K 2121/00 (2013.01);
Abstract

The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.


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