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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9839639 B1

PDFFull Text
Date of Patent:
Dec. 12, 2017

Filed:

Jan. 19, 2017

Neprilysin inhibitors

Applicant:

Theravance Biopharma R&d Ip, Llc, South San Francisco, CA (US);

Inventors:

Melissa Fleury, Brisbane, CA (US);

Anne-Marie Beausoliel, Redwood City, CA (US);

Adam D. Hughes, Half Moon Bay, CA (US);

Daniel D. Long, San Francisco, CA (US);

Donna A. A. Wilton, San Francisco, CA (US);

Assignee:

THERAVANCE BIOPHARMA R&D IP, LLC, South San Francisco, CA (US);

Attorneys:

Jeffrey A. Hagenah

Wendy Petka

Primary Examiner:

Kamal Saeed

Int. Cl.
CPC ...
A61K 31/505 (2006.01); A61K 31/415 (2006.01); A61K 31/4192 (2006.01); A61K 31/4196 (2006.01); A61K 31/4245 (2006.01); C07D 249/04 (2006.01); C07C 229/08 (2006.01); A61K 45/06 (2006.01); C07D 231/14 (2006.01); C07C 271/22 (2006.01); C07D 263/34 (2006.01); A61K 31/421 (2006.01); C07D 271/07 (2006.01); C07D 213/81 (2006.01); A61K 31/44 (2006.01); C07D 239/28 (2006.01); C07D 249/10 (2006.01); C07D 307/24 (2006.01); C07D 405/12 (2006.01); C07D 207/16 (2006.01); C07D 403/12 (2006.01); C07D 239/42 (2006.01); C07D 249/14 (2006.01); C07D 261/10 (2006.01); C07D 213/56 (2006.01);
U.S. Cl.
CPC ...
A61K 31/505 (2013.01); A61K 31/415 (2013.01); A61K 31/4192 (2013.01); A61K 31/4196 (2013.01); A61K 31/421 (2013.01); A61K 31/4245 (2013.01); A61K 31/44 (2013.01); A61K 45/06 (2013.01); C07C 229/08 (2013.01); C07C 271/22 (2013.01); C07D 207/16 (2013.01); C07D 213/56 (2013.01); C07D 213/81 (2013.01); C07D 231/14 (2013.01); C07D 239/28 (2013.01); C07D 239/42 (2013.01); C07D 249/04 (2013.01); C07D 249/10 (2013.01); C07D 249/14 (2013.01); C07D 261/10 (2013.01); C07D 263/34 (2013.01); C07D 271/07 (2013.01); C07D 307/24 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01);
Abstract

In one aspect, the invention relates to compounds having the formula I: where R, R, R, and R-Rare as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

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