The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2017
Filed:
Dec. 19, 2014
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Shuzhi Dong, Plainsboro, NJ (US);
Alexander Pasternak, Princeton, NJ (US);
Xin Gu, Scotch Plains, NJ (US);
Qinghong Fu, Plainsboro, NJ (US);
Jinlong Jiang, Scotch Plains, NJ (US);
Fa-Xiang Ding, Staten Island, NY (US);
Haifeng Tang, Metuchen, NJ (US);
Reynalda K. DeJesus, East Brunswick, NJ (US);
Takao Suzuki, Shanghai, CN;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.