The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 12, 2017

Filed:

May. 11, 2013
Applicants:

University of Virginia Patent Foundation, Charlottesville, VA (US);

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

J. Randall Moorman, Keswick, VA (US);

Douglas E. Lake, Charlottesville, VA (US);

Gordon F. Tomaselli, Lutherville, MD (US);

Deeptankar Demazumder, Baltimore, MD (US);

Assignees:

University of Virginia Patent Foundation, Charlottesville, VA (US);

The Johns Hopkins University, Baltimore, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/024 (2006.01); A61B 5/04 (2006.01); A61B 5/0456 (2006.01); A61B 5/00 (2006.01);
U.S. Cl.
CPC ...
A61B 5/02405 (2013.01); A61B 5/0006 (2013.01); A61B 5/04012 (2013.01); A61B 5/0456 (2013.01);
Abstract

A method of determining health and mortality includes obtaining a ventricular activation (RR) time series from a subject for multiple temporal intervals. The method also includes calculating a cardiac entropy in the RR time series over the temporal intervals using coefficient of sample entropy (COSEn). Additionally, the method includes comparing the cardiac entropy between the intervals to determine health and mortality. The absolute and relative changes in entropy over a patient's follow up period provide dynamic information regarding health and mortality risk. The determination of health and mortality can then be used to create a treatment plan for the subject.


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