The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2017
Filed:
Oct. 01, 2015
Samsung Life Public Welfare Foundation, Seoul, KR;
Chong Kun Dang Pharmaceutical Corp, Seoul, KR;
Yun Tae Kim, Gyeonggi-do, KR;
Byung-Ok Choi, Seoul, KR;
Sung Chul Jung, Seoul, KR;
Young Bin Hong, Seoul, KR;
So-Youn Woo, Seoul, KR;
Jin-Mo Park, Seoul, KR;
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION, Seoul, KR;
CHONG KUN DANG PHARMACEUTICAL CORP, Seoul, KR;
Abstract
The present invention relates to a HSP27 mutation (S135F) mediated Charcot-Marie-Tooth disease (CMT) animal model. Particularly, the vector expressing mutant HSP27 protein wherein the 135serine is substituted with phenylalanine has been injected in the mouse zygote and then the mouse harboring the expression vector was selected. The selected mouse was confirmed to display Charcot-Marie-Tooth disease phenotype, so that the animal model was expected to be efficiently used for the evaluation of the effect of Charcot-Marie-Tooth disease treating material candidates.