The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2017
Filed:
Feb. 14, 2007
Sebastien Rigali, Angleur, BE;
Mannfred Friedrich Bruno Titgemeyer, Möhrendorf, DE;
Gilles Philippus Van Wezel, Oegstgeest, NL;
Sebastien Rigali, Angleur, BE;
Mannfred Friedrich Bruno Titgemeyer, Möhrendorf, DE;
Gilles Philippus Van Wezel, Oegstgeest, NL;
Universiteit Leiden, Leiden, NL;
University of Liège, Angleur, BE;
Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, DE;
Abstract
Described are methods and means for metabolic engineering and improved product formation by a filamentous micro-organism or a low G+C gram-positive bacterium. Disclosed is that DasR and DasR binding sites play an important and universal role in the control of gene expression in micro-organisms. Based on this finding, provided are multiple useful applications, such as a method for regulating the expression of a gene of interest, a method for controlling metabolism, a method for decreasing undesired expression and many more. Moreover, provided are means that can be used to establish said methods: for example a micro-organism in which the DasR binding site in operable linkage with a particular gene has been modified to obtain increased or decreased expression of a protein (being a desired or undesired protein) encoded by said gene.