The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2017
Filed:
Nov. 19, 2014
Glaxosmithkline Llc, Wilmington, DE (US);
Charles A. Blum, Waltham, MA (US);
Richard Dana Caldwell, Brookline, MA (US);
Rebecca Casaubon, Cambridge, MA (US);
Jeremy S. Disch, Natick, MA (US);
Ryan Michael Fox, Collegeville, PA (US);
Karsten Koppetsch, Woburn, MA (US);
William Henry Miller, Collegeville, PA (US);
Pui Yee Ng, Waltham, MA (US);
Christopher Oalmann, Watertown, MA (US);
Robert B. Perni, Marlborough, MA (US);
Bruce G. Szczepankiewicz, Hopkinton, MA (US);
Brian White, Malden, MA (US);
GLAXOSMITHKLINE LLC, Wilmington, DE (US);
Abstract
The present invention relates to novel substituted bridged urea compounds of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.